Dezhi Liao, PhD

Associate Professor, Department of Neuroscience

Dezhi Liao

Contact Info

liaox020@umn.edu

Office Phone 612-626-3522

Office Address:
3-142 WMBB

Lab Address:
3-220 WMBB

Associate Professor, Department of Neuroscience


Research

Research Summary/Interests

Molecular and Cellular Mechanisms of Synaptic Plasticity

Activity-dependent modulation of glutamatergic synapses has been suggested to play important roles in learning and memory in adult brains, and the formation of synaptic connections in developmental brains. This modulation is at least partially mediated through the activation of “silent synapses,” synapses that contain NMDA receptors but not AMPA receptors. Such synapses are silent at a normal resting potential due to voltage-dependent magnesium blockade of NMDA receptors.

Our laboratory mainly uses electrophysiological, morphological and molecular biological techniques to investigate molecular and cellular mechanisms of activity-dependent synaptic plasticity. Particularly, we are interested in the cellular mechanisms responsible for the activation of silent synapses. It has been recently reported that silent synapses can be rapidly awakened through a rapid acquisition of AMPA receptors. Our goal is to understand the intracellular signaling pathways for the rapid synaptic targeting of AMPA receptors.

Publications

For a list of publications, see PubMed.

Teaching

Courses

NSCI 4105: Neurobiology Laboratory I (Fall and Summer semesters)