George L. Wilcox, PhD

Professor, Department of Neuroscience

George L. Wilcox

Contact Info

george@umn.edu

Office Phone 612-625-1474

Office Address:
4-136 Molecular & Cellular Biology (MCB)

Lab Address:
4-150 MCB

Research

Research Summary/Interests

Neurotransmission of Pain

Dr. Wilcox and colleagues are engaged in research into the spinal neurotransmission of pain and mechanisms underlying hyperalgesia, analgesia and analgesic tolerance. Studies of both excitatory and inhibitory neurotransmission in the rodent spinal cord apply behavioral, electrophysiological (both in vivo and in vitro),immunocytochemical and molecular techniques. Behavioral experiments define biologically relevant interactions, which are then examined at the cellular and molecular level using the more reductionist approaches. A key feature of research projects in this laboratory is open collaboration with laboratories located both here and at other universities.

One major thrust of these investigations examines neurotransmitters thought to mediate major components of excitatory neurotransmission from primary afferent sensory fibers to secondary projection neurons in spinal cord dorsal horn: the excitatory amino acids (EAAs) like glutamate and the neurokinins like substance P. Intense or prolonged excitatory transmission via both these pathways is thought to evoke long term synaptic plasticity and excitotoxicity, which may underlie the development of some chronic pain states.

A second major focus of work in the laboratory is the characterization of several inhibitory neurotransmitters and their receptors which together modulate this excitation. The neurotransmitters, enkephalin, serotonin and noradrenaline, inhibit various components of the incoming excitatory pain message in the dorsal horn via a number of inhibitory receptor subtypes. We are characterizing the interactions between these receptor subtypes and localizing them using transgenic mice, antisense oligonucleotides and immunocytochemical techniques.

Finally, Dr. Wilcox facilitates access for Neuroscience students to high performance computing laboratories on campus - The Laboratory for Computational Science & Engineering and The Minnesota Supercomputer Institute (MSI). High performance computers and visualization are now finding applications in biological imaging, macromolecular modeling and neuronal simulation. A recent neuroscience graduate student developed a new method to optimize correspondence between neuronal simulations and experimental structure-function data.

Publications

For a list of publications, see PubMed.

  • Bosaeus I, Wilcox G, Rothenberg E, Strauss BJ. Skeletal muscle mass in hospitalized elderly patients: comparison of measurements by single-frequency BIA and DXA. Clin Nutr. 2014;33(3):426-31.
  • Piletz JE, Aricioglu F, Cheng J-, Fairbanks CA, Gilad VH, Haenisch B, et al. Agmatine: clinical applications after 100 years in translation. Drug Discov Today. 2013;18(17-18):880-93.
  • Schuster DJ, Kitto KF, Overland AC, Messing RO, Stone LS, Fairbanks CA, et al. Protein kinase C? is required for spinal analgesic synergy between delta opioid and alpha-2A adrenergic receptor agonist pairs. J Neurosci. 2013;33(33):13538-46.
  • Metcalf MD, Yekkirala AS, Powers MD, Kitto KF, Fairbanks CA, Wilcox GL, et al. The ? opioid receptor agonist SNC80 selectively activates heteromeric ?-? opioid receptors. ACS Chem Neurosci. 2012;3(7):505-9.
  • Payne CM, Holubec H, Crowley-Skillicorn C, Nguyen H, Bernstein H, Wilcox G, et al. Maspin is a deoxycholate-inducible, anti-apoptotic stress-response protein differentially expressed during colon carcinogenesis. Clin Exp Gastroenterol. 2011;4:239-53.
  • Vulchanova L, Schuster DJ, Belur LR, Riedl MS, Podetz-Pedersen KM, Kitto KF, et al. Differential adeno-associated virus mediated gene transfer to sensory neurons following intrathecal delivery by direct lumbar puncture. Mol Pain. 2010;6:31.
  • Schmidt BL, Hamamoto DT, Simone DA, Wilcox GL. Mechanism of cancer pain. Mol Interv. 2010;10(3):164-78.
  • Ghazi IE, Sheng WS, Hu S, Reilly BG, Lokensgard JR, R Rock B, et al. Changes in the NMR metabolic profile of human microglial cells exposed to lipopolysaccharide or morphine. J Neuroimmune Pharmacol. 2010;5(4):574-81.
  • Fairbanks CA, Kitto KF, H Nguyen O, Stone LS, Wilcox GL. Clonidine and dexmedetomidine produce antinociceptive synergy in mouse spinal cord. Anesthesiology. 2009;110(3):638-47.
  • Riedl MS, Schnell SA, Overland AC, Chabot-Doré A-, Taylor AM, Ribeiro-da-Silva A, et al. Coexpression of alpha 2A-adrenergic and delta-opioid receptors in substance P-containing terminals in rat dorsal horn. J Comp Neurol. 2009;513(4):385-98.
  • Stein C, J Clark D, Oh U, Vasko MR, Wilcox GL, Overland AC, et al. Peripheral mechanisms of pain and analgesia. Brain Res Rev. 2009;60(1):90-113.
  • Fairbanks CA, Stone LS, Wilcox GL. Pharmacological profiles of alpha 2 adrenergic receptor agonists identified using genetically altered mice and isobolographic analysis. Pharmacol Ther. 2009;123(2):224-38.
  • Overland AC, Kitto KF, Chabot-Doré A-, Rothwell PE, Fairbanks CA, Stone LS, et al. Protein kinase C mediates the synergistic interaction between agonists acting at alpha2-adrenergic and delta-opioid receptors in spinal cord. J Neurosci. 2009;29(42):13264-73.
  • Wade CL, Eskridge LL, H Nguyen OX, Kitto KF, Stone LS, Wilcox G, et al. Immunoneutralization of agmatine sensitizes mice to micro-opioid receptor tolerance. J Pharmacol Exp Ther. 2009;331(2):539-46.
  • Schreiber KL, Beitz AJ, Wilcox GL. Activation of spinal microglia in a murine model of peripheral inflammation-induced, long-lasting contralateral allodynia. Neurosci Lett. 2008;440(1):63-7.
  • Stone LS, Kitto KF, Eisenach JC, Fairbanks CA, Wilcox GL. ST91 [2-(2,6-diethylphenylamino)-2-imidazoline hydrochloride]-mediated spinal antinociception and synergy with opioids persists in the absence of functional alpha-2A- or alpha-2C-adrenergic receptors. J Pharmacol Exp Ther. 2007;323(3):899-906.
  • Vit J-, Ohara PT, Tien DA, Fike JR, Eikmeier L, Beitz A, et al. The analgesic effect of low dose focal irradiation in a mouse model of bone cancer is associated with spinal changes in neuro-mediators of nociception. Pain. 2006;120(1-2):188-201.
  • Wacnik PW, Eikmeier LJ, Simone DA, Wilcox GL, Beitz AJ. Nociceptive characteristics of tumor necrosis factor-alpha in naive and tumor-bearing mice. Neuroscience. 2005;132(2):479-91.
  • Wacnik PW, Baker CM, Herron MJ, Kren BT, Blazar BR, Wilcox GL, et al. Tumor-induced mechanical hyperalgesia involves CGRP receptors and altered innervation and vascularization of DsRed2 fluorescent hindpaw tumors. Pain. 2005;115(1-2):95-106.
  • Zhao C, Wacnik PW, Tall JM, Johns DC, Wilcox GL, Meyer RA, et al. Analgesic effects of a soy-containing diet in three murine bone cancer pain models. J Pain. 2004;5(2):104-10.
  • Stone LS, Vulchanova L, Riedl MS, Williams FG, Wilcox GL, Elde R. Effects of peripheral nerve injury on delta opioid receptor (DOR) immunoreactivity in the rat spinal cord. Neurosci Lett. 2004;361(1-3):208-11.PubMed (link is external) Google Scholar (link is external) Tagged XML
  • Stone LS, Wilcox GL. Alpha-2-adrenergic and opioid receptor additivity in rat locus coeruleus neurons. Neurosci Lett. 2004;361(1-3):265-8.PubMed (link is external) Google Scholar (link is external) Tagged XML
  • Stone LS, Fairbanks CA, Wilcox GL. Moxonidine, a mixed alpha(2)-adrenergic and imidazoline receptor agonist, identifies a novel adrenergic target for spinal analgesia. Ann N Y Acad Sci. 2003;1009:378-85.PubMed (link is external) Google Scholar (link is external) Tagged XML
  • Wacnik PW, Kehl LJ, Trempe TM, Ramnaraine ML, Beitz AJ, Wilcox GL. Tumor implantation in mouse humerus evokes movement-related hyperalgesia exceeding that evoked by intramuscular carrageenan. Pain. 2003;101(1-2):175-86.PubMed (link is external) Google Scholar (link is external) Tagged XML
  • Yu C-, Fairbanks CA, Wilcox GL, Yezierski RP. Effects of agmatine, interleukin-10, and cyclosporin on spontaneous pain behavior after excitotoxic spinal cord injury in rats. J Pain. 2003;4(3):129-40.PubMed (link is external) Google Scholar (link is external) Tagged XML
  • Kehl LJ, Hamamoto DT, Wacnik PW, Croft DL, Norsted BD, Wilcox GL, et al. A cannabinoid agonist differentially attenuates deep tissue hyperalgesia in animal models of cancer and inflammatory muscle pain. Pain. 2003;103(1-2):175-86.PubMed (link is external) Google Scholar (link is external) Tagged XML
  • Fairbanks CA, Stone LS, Kitto KF, H Nguyen O, Posthumus IJ, Wilcox GL. alpha(2C)-Adrenergic receptors mediate spinal analgesia and adrenergic-opioid synergy. J Pharmacol Exp Ther. 2002;300(1):282-90.PubMed (link is external) Google Scholar (link is external) Tagged XML
  • Laughlin TM, Tram KV, Wilcox GL, Birnbaum AK. Comparison of antiepileptic drugs tiagabine, lamotrigine, and gabapentin in mouse models of acute, prolonged, and chronic nociception. J Pharmacol Exp Ther. 2002;302(3):1168-75.PubMed (link is external) Google Scholar (link is external) Tagged XML
  • Wacnik PW, Eikmeier LJ, Ruggles TR, Ramnaraine ML, Walcheck BK, Beitz AJ, et al. Functional interactions between tumor and peripheral nerve: morphology, algogen identification, and behavioral characterization of a new murine model of cancer pain. J Neurosci. 2001;21(23):9355-66.PubMed (link is external) Google Scholar (link is external) Tagged XML

  • Cain DM, Wacnik PW, Turner M, Wendelschafer-Crabb G, Kennedy WR, Wilcox GL, et al. Functional interactions between tumor and peripheral nerve: changes in excitability and morphology of primary afferent fibers in a murine model of cancer pain. J Neurosci. 2001;21(23):9367-76.PubMed (link is external) Google Scholar (link is external) Tagged XML

  • Yu CG, Marcillo AE, Fairbanks CA, Wilcox GL, Yezierski RP. Agmatine improves locomotor function and reduces tissue damage following spinal cord injury. Neuroreport. 2000;11(14):3203-7.PubMed (link is external) Google Scholar (link is external) Tagged XML

  • Fairbanks CA, Posthumus IJ, Kitto KF, Stone LS, Wilcox GL. Moxonidine, a selective imidazoline/alpha(2) adrenergic receptor agonist, synergizes with morphine and deltorphin II to inhibit substance P-induced behavior in mice. Pain. 2000;84(1):13-20.PubMed (link is external) Google Scholar (link is external) Tagged XML

  • Laughlin TM, Bethea JR, Yezierski RP, Wilcox GL. Cytokine involvement in dynorphin-induced allodynia. Pain. 2000;84(2-3):159-67.PubMed (link is external) Google Scholar (link is external) Tagged XML

  • Fairbanks CA, Wilcox GL. Spinal plasticity of acute opioid tolerance. J Biomed Sci. 2000;7(3):200-12.PubMed (link is external) Google Scholar (link is external) Tagged XML

  • Fairbanks CA, Nguyen HO, Grocholski BM, Wilcox GL. Moxonidine, a selective imidazoline-alpha2 -adrenergic receptor agonist, produces spinal synergistic antihyperalgesia with morphine in nerve-injured mice. Anesthesiology. 2000;93(3):765-73.PubMed (link is external) Google Scholar (link is external) Tagged XML

  • Fairbanks CA, Schreiber KL, Brewer KL, Yu CG, Stone LS, Kitto KF, et al. Agmatine reverses pain induced by inflammation, neuropathy, and spinal cord injury. Proc Natl Acad Sci USA. 2000;97(19):10584-9.PubMed (link is external) Google Scholar (link is external) Tagged XML

  • Fairbanks CA, Wilcox GL. Moxonidine, a selective alpha2-adrenergic and imidazoline receptor agonist, produces spinal antinociception in mice. J Pharmacol Exp Ther. 1999;290(1):403-12.PubMed (link is external) Google Scholar (link is external) Tagged XML

  • Laughlin TM, Kitto KF, Wilcox GL. Redox manipulation of NMDA receptors in vivo: alteration of acute pain transmission and dynorphin-induced allodynia. Pain. 1999;80(1-2):37-43.PubMed (link is external) Google Scholar (link is external) Tagged XML

  • Stone LS, Vulchanova L, Riedl MS, Wang J, Williams FG, Wilcox GL, et al. Effects of peripheral nerve injury on alpha-2A and alpha-2C adrenergic receptor immunoreactivity in the rat spinal cord. Neuroscience. 1999;93(4):1399-407.PubMed (link is external) Google Scholar (link is external) Tagged XML

  • Fairbanks CA, Wilcox GL. Moxonidine, a selective alpha2-adrenergic and imidazoline receptor agonist, produces spinal antinociception in mice. J Pharmacol Exp Ther. 1999;290(1):403-12.PubMed (link is external) Google Scholar (link is external) Tagged XML

  • Stone LS, Broberger C, Vulchanova L, Wilcox GL, Hökfelt T, Riedl MS, et al. Differential distribution of alpha2A and alpha2C adrenergic receptor immunoreactivity in the rat spinal cord. J Neurosci. 1998;18(15):5928-37.PubMed (link is external) Google Scholar (link is external) Tagged XML

  • Stone LS, MacMillan LB, Kitto KF, Limbird LE, Wilcox GL. The alpha2a adrenergic receptor subtype mediates spinal analgesia evoked by alpha2 agonists and is necessary for spinal adrenergic-opioid synergy. J Neurosci. 1997;17(18):7157-65.PubMed (link is external) Google Scholar (link is external) Tagged XML

  • Wotta DR, Birnbaum AK, Wilcox GL, Elde R, Law PY. mu-opioid receptor regulates CFTR coexpressed in Xenopus oocytes in a cAMP independent manner. Brain Res Mol Brain Res. 1997;44(1):55-65.PubMed (link is external) Google Scholar (link is external) Tagged XML

  • Kehl LJ, Fairbanks CA, Laughlin TM, Wilcox GL. Neurogenesis in postnatal rat spinal cord: a study in primary culture. Science. 1997;276(5312):586-9.PubMed (link is external) Google Scholar (link is external) Tagged XML

  • Laughlin TM, Vanderah TW, Lashbrook J, Nichols ML, Ossipov M, Porreca F, et al. Spinally administered dynorphin A produces long-lasting allodynia: involvement of NMDA but not opioid receptors. Pain. 1997;72(1-2):253-60.PubMed (link is external) Google Scholar (link is external) Tagged XML

  • Fairbanks CA, Wilcox GL. Acute tolerance to spinally administered morphine compares mechanistically with chronically induced morphine tolerance. J Pharmacol Exp Ther. 1997;282(3):1408-17.PubMed (link is external) Google Scholar (link is external) Tagged XML

  • Stone LS, Fairbanks CA, Laughlin TM, Nguyen HO, Bushy TM, Wessendorf MW, et al. Spinal analgesic actions of the new endogenous opioid peptides endomorphin-1 and -2. Neuroreport. 1997;8(14):3131-5.PubMed (link is external) Google Scholar (link is external) Tagged XML

  • Vanderah TW, Laughlin T, Lashbrook JM, Nichols ML, Wilcox GL, Ossipov MH, et al. Single intrathecal injections of dynorphin A or des-Tyr-dynorphins produce long-lasting allodynia in rats: blockade by MK-801 but not naloxone. Pain. 1996;68(2-3):275-81.PubMed (link is external) Google Scholar (link is external) Tagged XML

  • Lukashin AV, Amirikian BR, Mozhaev VL, Wilcox GL, Georgopoulos AP. Modeling motor cortical operations by an attractor network of stochastic neurons. Biol Cybern. 1996;74(3):255-61.PubMed (link is external) Google Scholar (link is external) Tagged XML

  • Roche AK, Cook M, Wilcox GL, Kajander KC. A nitric oxide synthesis inhibitor (L-NAME) reduces licking behavior and Fos-labeling in the spinal cord of rats during formalin-induced inflammation. Pain. 1996;66(2-3):331-41.PubMed (link is external) Google Scholar (link is external) Tagged XML

  • Lai J, Riedl M, Stone LS, Arvidsson U, Bilsky EJ, Wilcox GL, et al. Immunofluorescence analysis of antisense oligodeoxynucleotide-mediated 'knock-down' of the mouse delta opioid receptor in vitro and in vivo. Neurosci Lett. 1996;213(3):205-8.PubMed (link is external) Google Scholar (link is external) Tagged XML

  • West RM, Wilcox GL. A renumbering method to decrease matrix banding in equations describing branched neuron-like structures. J Neurosci Methods. 1996;68(1):15-9.PubMed (link is external) Google Scholar (link is external) Tagged XML

  • Budai D, Wilcox GL, Larson AA. Effects of nitric oxide availability on responses of spinal wide dynamic range neurons to excitatory amino acids. Eur J Pharmacol. 1995;278(1):39-47.PubMed (link is external) Google Scholar (link is external) Tagged XML

  • Bétoin F, Advenier C, Fardin V, Wilcox G, Lavarenne J, Eschalier A. In vitro and in vivo evidence for a tachykinin NK1 receptor antagonist effect of vapreotide, an analgesic cyclic analog of somatostatin. Eur J Pharmacol. 1995;279(2-3):241-9.PubMed (link is external) Google Scholar (link is external) Tagged XML

  • Birnbaum AK, Wotta DR, Law PY, Wilcox GL. Functional expression of adrenergic and opioid receptors in Xenopus oocytes: interaction between alpha 2- and beta 2-adrenergic receptors. Brain Res Mol Brain Res. 1995;28(1):72-80.PubMed (link is external) Google Scholar (link is external) Tagged XML

  • Wu HH, Lester BR, Sun Z, Wilcox GL. Antinociception following implantation of mouse B16 melanoma cells in mouse and rat spinal cord. Pain. 1994;56(2):203-10.PubMed (link is external) Google Scholar (link is external) Tagged XML

  • Lukashin AV, Wilcox GL, Georgopoulos AP. Overlapping neural networks for multiple motor engrams. Proc Natl Acad Sci USA. 1994;91(18):8651-4.PubMed (link is external) Google Scholar (link is external) Tagged XML

  • Wu HH, Wilcox GL, McLoon SC. Implantation of AtT-20 or genetically modified AtT-20/hENK cells in mouse spinal cord induced antinociception and opioid tolerance. J Neurosci. 1994;14(8):4806-14.PubMed (link is external) Google Scholar (link is external) Tagged XML

  • Laughlin TM, Larson AA, Wilcox GL. Mechanisms of induction of persistent nociception by dynorphin. J Pharmacol Exp Ther. 2001;299(1):6-11.PubMed (link is external) Google Scholar (link is external) Tagged XML

  • Cain DM, Wacnik PW, Eikmeier L, Beitz A, Wilcox GL, Simone DA. Functional interactions between tumor and peripheral nerve in a model of cancer pain in the mouse. Pain Med. 2001;2(1):15-23.PubMed (link is external) Google Scholar (link is external) Tagged XML

  • Wu HH, Wilcox GL, McLoon SC. Implantation of AtT-20 or genetically modified AtT-20/hENK cells in mouse spinal cord induced antinociception and opioid tolerance. J Neurosci. 1994;14(8):4806-14.PubMed (link is external) Google Scholar (link is external) Tagged XML

  • Budai D, Kehl LJ, Poliac GI, Wilcox GL. An iconographic program for computer-controlled whole-cell voltage clamp experiments. J Neurosci Methods. 1993;48(1-2):65-74.PubMed (link is external) Google Scholar (link is external) Tagged XML

  • Callaway JE, Lai J, Haselbeck B, Baltaian M, Bonnesen SP, Weickmann J, et al. Modification of the C terminus of cecropin is essential for broad-spectrum antimicrobial activity. Antimicrob Agents Chemother. 1993;37(8):1614-9.PubMed (link is external) Google Scholar (link is external) Tagged XML

  • Alhaider AA, Hamon M, Wilcox GL. Intrathecal 5-methoxy-N,N-dimethyltryptamine in mice modulates 5-HT1 and 5-HT3 receptors. Eur J Pharmacol. 1993;249(2):151-60.PubMed (link is external) Google Scholar (link is external) Tagged XML

  • Studnicka GM, Lei SP, Lin HC, Wilcox G. Subcloning for DNA sequencing. Methods Mol Biol. 1993;23:69-74.PubMed (link is external) Google Scholar (link is external) Tagged XML

  • Wu HH, McLoon SC, Wilcox GL. Antinociception following implantation of AtT-20 and genetically modified AtT-20/hENK cells in rat spinal cord. J Neural Transplant Plast. 1993;4(1):15-26.PubMed (link is external) Google Scholar (link is external) Tagged XML

  • Alhaider AA, Wilcox GL. Differential roles of 5-hydroxytryptamine1A and 5-hydroxytryptamine1B receptor subtypes in modulating spinal nociceptive transmission in mice. J Pharmacol Exp Ther. 1993;265(1):378-85.PubMed (link is external) Google Scholar (link is external) Tagged XML

  • Clarke P, Lee JH, Burke K, Wilcox G. Mutations in the araC gene of Salmonella typhimurium LT2 which affect both activator and auto-regulatory functions of the AraC protein. Gene. 1992;117(1):31-7.PubMed (link is external) Google Scholar (link is external) Tagged XML

  • Haley JE, Wilcox GL, Chapman PF. The role of nitric oxide in hippocampal long-term potentiation. Neuron. 1992;8(2):211-6.PubMed (link is external) Google Scholar (link is external) Tagged XML

  • Lee JH, Wilcox GL, Beitz AJ. Nitric oxide mediates Fos expression in the spinal cord induced by mechanical noxious stimulation. Neuroreport. 1992;3(10):841-4.PubMed (link is external) Google Scholar (link is external) Tagged XML

  • Budai D, Wilcox GL, Larson AA. Enhancement of NMDA-evoked neuronal activity by glycine in the rat spinal cord in vivo. Neurosci Lett. 1992;135(2):265-8.PubMed (link is external) Google Scholar (link is external) Tagged XML

  • Kitto KF, Haley JE, Wilcox GL. Involvement of nitric oxide in spinally mediated hyperalgesia in the mouse. Neurosci Lett. 1992;148(1-2):1-5.PubMed (link is external) Google Scholar (link is external) Tagged XML

  • Budai D, Wilcox GL, Larson AA. Modulation of N-methyl-D-aspartate and (R,S)-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) responses of spinal nociceptive neurons by a N-terminal fragment of substance P. Eur J Pharmacol. 1992;216(3):441-4.PubMed (link is external) Google Scholar (link is external) Tagged XML

  • Roerig SC, Lei S, Kitto K, Hylden JK, Wilcox GL. Spinal interactions between opioid and noradrenergic agonists in mice: multiplicativity involves delta and alpha-2 receptors. J Pharmacol Exp Ther. 1992;262(1):365-74.PubMed (link is external) Google Scholar (link is external) Tagged XML

  • Lei SP, Lin HC, Wang SS, Higaki P, Wilcox G. Characterization of the Erwinia carotovora peh gene and its product polygalacturonase. Gene. 1992;117(1):119-24.PubMed (link is external) Google Scholar (link is external) Tagged XML

  • Nishitani J, Wilcox G. Cloning and characterization of the L-rhamnose regulon in Salmonella typhimurium LT2. Gene. 1991;105(1):37-42.PubMed (link is external) Google Scholar (link is external) Tagged XML

  • Lei SZ, Lipkowski AW, Wilcox GL. Opioid and neurokinin activities of substance P fragments and their analogs. Eur J Pharmacol. 1991;193(2):209-15.PubMed (link is external) Google Scholar (link is external) Tagged XML

  • Roerig SC, Hoffman RG, Takemori AE, Wilcox GL, Fujimoto JM. Isobolographic analysis of analgesic interactions between intrathecally and intracerebroventricularly administered fentanyl, morphine and D-Ala2-D-Leu5-enkephalin in morphine-tolerant and nontolerant mice. J Pharmacol Exp Ther. 1991;257(3):1091-9.PubMed (link is external) Google Scholar (link is external) Tagged XML

  • Alhaider AA, Lei SZ, Wilcox GL. Spinal 5-HT3 receptor-mediated antinociception: possible release of GABA. J Neurosci. 1991;11(7):1881-8.PubMed (link is external) Google Scholar (link is external) Tagged XML

  • Aanonsen LM, Lei S, Wilcox GL. Excitatory amino acid receptors and nociceptive neurotransmission in rat spinal cord. Pain. 1990;41(3):309-21.PubMed (link is external) Google Scholar (link is external) Tagged XML

  • Stoltzfus L, Wilcox G. Effect of mutations in the cyclic AMP receptor protein-binding site on araBAD and araC expression. J Bacteriol. 1989;171(2):1178-84.PubMed (link is external) Google Scholar (link is external) Tagged XML

  • Hwang AS, Wilcox GL. Baclofen, gamma-aminobutyric acidB receptors and substance P in the mouse spinal cord. J Pharmacol Exp Ther. 1989;248(3):1026-33.PubMed (link is external) Google Scholar (link is external) Tagged XML

  • Aanonsen LM, Wilcox GL. Muscimol, gamma-aminobutyric acidA receptors and excitatory amino acids in the mouse spinal cord. J Pharmacol Exp Ther. 1989;248(3):1034-8.PubMed (link is external) Google Scholar (link is external) Tagged XML

  • Gaumann DM, Yaksh TL, Post C, Wilcox GL, Rodriguez M. Intrathecal somatostatin in cat and mouse studies on pain, motor behavior, and histopathology. Anesth Analg. 1989;68(5):623-32.PubMed (link is external) Google Scholar (link is external) Tagged XML

  • Wilcox G, Studnicka GM. Expression of foreign proteins in microorganisms. Biotechnol Appl Biochem. 1988;10(6):500-9.PubMed (link is external) Google Scholar (link is external) Tagged XML

  • Wilcox GL, Quiocho FA, Levinthal C, Harvey SC, Maggiora GM, McCammon JA. Symposium overview. Minnesota Conference on Supercomputing in Biology: Proteins, Nucleic Acids, and Water. J Comput Aided Mol Des. 1988;1(4):271-81.PubMed (link is external) Google Scholar (link is external) Tagged XML

  • Lei SP, Lin HC, Wang SS, Wilcox G. Characterization of the Erwinia carotovora pelA gene and its product pectate lyase A. Gene. 1988;62(1):159-64.PubMed (link is external) Google Scholar (link is external) Tagged XML

  • Wilcox GL. Pharmacological studies of grooming and scratching behavior elicited by spinal substance P and excitatory amino acids. Ann N Y Acad Sci. 1988;525:228-36.PubMed (link is external) Google Scholar (link is external) Tagged XML

  • Abernathey CD, Kooistra KL, Wilcox GL, Laws ER. New xenograft model for assessing experimental therapy of central nervous system tumors: human glioblastoma in the intrathecal compartment of the nude mouse. Neurosurgery. 1988;22(5):877-81.PubMed (link is external) Google Scholar (link is external) Tagged XML

  • Cass LG, Wilcox G. Novel activation of araC expression and a DNA site required for araC autoregulation in Escherichia coli B/r. J Bacteriol. 1988;170(9):4174-80.PubMed (link is external) Google Scholar (link is external) Tagged XML

  • Aanonsen LM, Wilcox GL. Nociceptive action of excitatory amino acids in the mouse: effects of spinally administered opioids, phencyclidine and sigma agonists. J Pharmacol Exp Ther. 1987;243(1):9-19.PubMed (link is external) Google Scholar (link is external) Tagged XML

  • Burke KA, Wilcox G. The araC gene of Citrobacter freundii. Gene. 1987;61(3):243-52.PubMed (link is external) Google Scholar (link is external) Tagged XML

  • Hwang AS, Wilcox GL. Analgesic properties of intrathecally administered heterocyclic antidepressants. Pain. 1987;28(3):343-55.PubMed (link is external) Google Scholar (link is external) Tagged XML

  • Wilcox GL, Carlsson KH, Jochim A, Jurna I. Mutual potentiation of antinociceptive effects of morphine and clonidine on motor and sensory responses in rat spinal cord. Brain Res. 1987;405(1):84-93.PubMed (link is external) Google Scholar (link is external) Tagged XML

  • Wigdor S, Wilcox GL. Central and systemic morphine-induced antinociception in mice: contribution of descending serotonergic and noradrenergic pathways. J Pharmacol Exp Ther. 1987;242(1):90-5.PubMed (link is external) Google Scholar (link is external) Tagged XML

  • Lei SP, Lin HC, Wang SS, Callaway J, Wilcox G. Characterization of the Erwinia carotovora pelB gene and its product pectate lyase. J Bacteriol. 1987;169(9):4379-83.PubMed (link is external) Google Scholar (link is external) Tagged XML

  • Lee JH, Burke K, Wilcox G. Mutations resulting in promoter-like sequences which enhance the expression of araC in Salmonella typhimurium. Gene. 1986;46(1):113-21.PubMed (link is external) Google Scholar (link is external) Tagged XML

  • Cass LG, Wilcox G. Mutations in the araC regulatory gene of Escherichia coli B/r that affect repressor and activator functions of AraC protein. J Bacteriol. 1986;166(3):892-900.PubMed (link is external) Google Scholar (link is external) Tagged XML

  • Aanonsen LM, Wilcox GL. Phencyclidine selectively blocks a spinal action of N-methyl-D-aspartate in mice. Neurosci Lett. 1986;67(2):191-7.PubMed (link is external) Google Scholar (link is external) Tagged XML

  • Hwang AS, Wilcox GL. Intradermal hypertonic saline-induced behavior as a nociceptive test in mice. Life Sci. 1986;38(26):2389-96.PubMed (link is external) Google Scholar (link is external) Tagged XML

  • Hylden JL, Wilcox GL. Antinociceptive effect of morphine on rat spinothalamic tract and other dorsal horn neurons. Neuroscience. 1986;19(2):393-401.PubMed (link is external) Google Scholar (link is external) Tagged XML

  • Lin HC, Lei SP, Wilcox G. The araBAD operon of Salmonella typhimurium LT2. II. Nucleotide sequence of araA and primary structure of its product, L-arabinose isomerase. Gene. 1985;34(1):123-8.PubMed (link is external) Google Scholar (link is external) Tagged XML

  • Lin HC, Lei SP, Studnicka G, Wilcox G. The araBAD operon of Salmonella typhimurium LT2. III. Nucleotide sequence of araD and its flanking regions, and primary structure of its product, L-ribulose-5-phosphate 4-epimerase. Gene. 1985;34(1):129-34.PubMed (link is external) Google Scholar (link is external) Tagged XML

  • Lei SP, Lin HC, Heffernan L, Wilcox G. Cloning of the pectate lyase genes from Erwinia carotovora and their expression in Escherichia coli. Gene. 1985;35(1-2):63-70.PubMed (link is external) Google Scholar (link is external) Tagged XML

  • Lin HC, Lei SP, Wilcox G. An improved DNA sequencing strategy. Anal Biochem. 1985;147(1):114-9.PubMed (link is external) Google Scholar (link is external) Tagged XML

  • Lei SP, Lin HC, Heffernan L, Wilcox G. Evidence that polygalacturonase is a virulence determinant in Erwinia carotovora. J Bacteriol. 1985;164(2):831-5.PubMed (link is external) Google Scholar (link is external) Tagged XML

  • Lin HC, Lei SP, Wilcox G. The araBAD operon of Salmonella typhimurium LT2. I. Nucleotide sequence of araB and primary structure of its product, ribulokinase. Gene. 1985;34(1):111-22.PubMed (link is external) Google Scholar (link is external) Tagged XML

  • Lei SP, Lin HC, Heffernan L, Wilcox G. araB Gene and nucleotide sequence of the araC gene of Erwinia carotovora. J Bacteriol. 1985;164(2):717-22.PubMed (link is external) Google Scholar (link is external) Tagged XML

  • Al-Zarban S, Heffernan L, Nishitani J, Ransone L, Wilcox G. Positive control of the L-rhamnose genetic system in Salmonella typhimurium LT2. J Bacteriol. 1984;158(2):603-8.PubMed (link is external) Google Scholar (link is external) Tagged XML

  • Miyada CG, Stoltzfus L, Wilcox G. Regulation of the araC gene of Escherichia coli: catabolite repression, autoregulation, and effect on araBAD expression. Proc Natl Acad Sci USA. 1984;81(13):4120-4.PubMed (link is external) Google Scholar (link is external) Tagged XML

  • Wilcox GL, Giesler GJ. An instrument using a multiple layer Peltier device to change skin temperature rapidly. Brain Res Bull. 1984;12(1):143-6.PubMed (link is external) Google Scholar (link is external) Tagged XML

  • Roerig SC, O'Brien SM, Fujimoto JM, Wilcox GL. Tolerance to morphine analgesia: decreased multiplicative interaction between spinal and supraspinal sites. Brain Res. 1984;308(2):360-3.PubMed (link is external) Google Scholar (link is external) Tagged XML

  • Kehl LJ, Wilcox GL. Anti-nociceptive effect of tricyclic anti-depressants following intrathecal administration. Anesth Prog. 1984;31(2):82-4.PubMed (link is external) Google Scholar (link is external) Tagged XML

  • Larson AA, Wilcox GL. Synergistic behavioral effects of serotonin and tryptamine injected intrathecally in mice. Neuropharmacology. 1984;23(12A):1415-8.PubMed (link is external) Google Scholar (link is external) Tagged XML

  • Horwitz AH, Miyada CG, Wilcox G. Functional limits of the araIc promoter suggest an additional regulatory site for araBAD expression. J Bacteriol. 1984;158(1):141-7.PubMed (link is external) Google Scholar (link is external) Tagged XML

  • Lee JH, Nishitani J, Wilcox G. Genetic characterization of Salmonella typhimurium LT2 ara mutations. J Bacteriol. 1984;158(1):344-6.PubMed (link is external) Google Scholar (link is external) Tagged XML

  • Miyada CG, Sheppard DE, Wilcox G. Five mutations in the promoter region of the araBAD operon of Escherichia coli B/r. J Bacteriol. 1983;156(2):765-72.PubMed (link is external) Google Scholar (link is external) Tagged XML

  • Hylden JL, Wilcox GL. Antinociceptive action of intrathecal neurotensin in mice. Peptides. 1983;4(4):517-20.PubMed (link is external) Google Scholar (link is external) Tagged XML

  • Hylden JL, Wilcox GL. Pharmacological characterization of substance P-induced nociception in mice: modulation by opioid and noradrenergic agonists at the spinal level. J Pharmacol Exp Ther. 1983;226(2):398-404.PubMed (link is external) Google Scholar (link is external) Tagged XML

  • Hylden JL, Wilcox GL. Intrathecal serotonin in mice: analgesia and inhibition of a spinal action of substance P. Life Sci. 1983;33(8):789-95.PubMed (link is external) Google Scholar (link is external) Tagged XML

  • Clarke P, Lin HC, Wilcox G. Ultraviolet imaging: a simple method for detecting nucleic acids in preparative gels. Anal Biochem. 1982;124(1):88-91.PubMed (link is external) Google Scholar (link is external) Tagged XML

  • Wilcox GL. Correlates of nociception and antinociception in dorsal root potentials in the rat. Neuropharmacology. 1982;21(8):745-50.PubMed (link is external) Google Scholar (link is external) Tagged XML

  • Seybold VS, Hylden JL, Wilcox GL. Intrathecal substance P and somatostatin in rats: behaviors indicative of sensation. Peptides. 1982;3(1):49-54.PubMed (link is external) Google Scholar (link is external) Tagged XML

  • Hylden JL, Wilcox GL. Intrathecal opioids block a spinal action of substance P in mice: functional importance of both mu- and delta-receptors. Eur J Pharmacol. 1982;86(1):95-8.PubMed (link is external) Google Scholar (link is external) Tagged XML

  • Lee JH, Russo RJ, Heffernan L, Wilcox G. Regulation of L-arabinose transport in Salmonella typhimurium LT2. Mol Gen Genet. 1982;185(1):136-41.PubMed (link is external) Google Scholar (link is external) Tagged XML

  • Miyada CG, Soberón X, Itakura K, Wilcox G. The use of synthetic oligodeoxyribonucleotides to produce specific deletions in the araBAD promoter of Escherichia coli B/r. Gene. 1982;17(2):167-77.PubMed (link is external) Google Scholar (link is external) Tagged XML

  • Clarke P, Lin HC, Wilcox G. The nucleotide sequence of the araC regulatory gene in Salmonella typhimurium LT2. Gene. 1982;18(2):157-63.PubMed (link is external) Google Scholar (link is external) Tagged XML

Teaching

Courses

NSCI 4105: Neurobiology Laboratory I (Fall and Summer semesters); NSCI 8221: Neurobiology of Pain and Analgesia (Fall semester)