Neuroscience is the collective scientific effort to understand the brain. It is an interdisciplinary science collaborating with fields such as chemistry, engineering, and psychology. The Department of Neuroscience at the University of Minnesota Medical School is committed to providing excellence in research, education, and public service.
The Inaugural 2016 Wallin Neuroscience Discovery Day featured plenary speaker, Dr. Thomas Südhof, of Stanford University and Nobel Prize Laureate in Physiology or Medicine (2013). The title of his lecture was,"Neurexins in synapse specification and synaptic transmission: implications for neuropsychiatric disorders.”
Congratulations to Dr. Michael Lee who has received a $2.2 million dollar award from the National Institute of Neurological Disorders and Stroke for a project titled, "Pathological role of c-Abi in alpha-synucleinoapathy."
Congratulations to Drs. Michael Lee and Dezhi Liao, who have been awarded a prestigious $1 million dollar Mayo Partnership Grant by the state of Minnesota. The grant, "Molecular Mechanism of Novel Small Molecule Therapeutics for Alzheimer's Disease," partners with Dr. Eugenia Trushina, Neurology and Pharmacology, at the Mayo Clinic.
Dr. Esther Krook-Magnuson is using a technique called optogenetics to shed light on what happens during an epileptic seizure. Optogenetics is a new field that has been picking up steam in the last five to ten years. Esther's work will help scientists and physicians to better understand brain circuits so that they can develop targeted therapies to help stop seizures.
The AAMC and the Group on Research Advancement and Development (GRAND) recently held a contest that asked member institutions to submit videos capturing the importance of basic science research. Dr. David Redish, Ph.D., won second place over two dozen entries.
Congratulations to Dr. Vulchanova for her recent NIH U18 Cooperative Agreement award for, Selective Peripheral Neuromodulation through Organ-Specific AAV-Mediated Gene Transfer. Dr. Vulchanova's grant will provide proof-of-concept for a therapeutic approach to the modulation of nerve activity based on delivery of genes with the goal of enabling selective neurmodulation. The study will also test tools that may help to control the peripheral neural circuits that regulate individual organ.
Dr. Alfonso Araque and his colleagues have just published a paper in Science, August 14, 2015, volume 349, Circuit-Specific Signaling in Astrocyte-Neruon Networks in Basal Ganglia Pathways.
Mechanisms of neurodegenerative disorders
Dr. Silvain Lesne’s laboratory aims to understand the molecular and cellular mechanisms triggered by proteins abnormally aggregating in cerebral brain tissues during the course of neurodegenerative disorders, with a specific focus on Alzheimer’s disease.